Identification of feline immunodeficiency virus rev gene activity
نویسندگان
چکیده
منابع مشابه
Identification of feline immunodeficiency virus rev gene activity.
We constructed 16 deletion mutants from an infectious molecular clone of feline immunodeficiency virus (FIV) and a reporter plasmid carrying the bacterial chloramphenicol acetyltransferase (CAT) gene to identify the rev transactivator activity of the virus. Cotransfections of various mutants and the rev reporter clone bearing a portion of FIV env in addition to the CAT gene revealed that the se...
متن کاملFeline immunodeficiency virus gene expression: analysis of the RNA splicing pattern and the monocistronic rev mRNA.
The transcription pattern of the feline immunodeficiency virus (FIV) genome in a feline CD4+ cell line was examined. In addition to the genomic RNA (9.2 kb), at least five FIV-specific transcripts [5.2, 4.4 (doublet), 1.7 and 1.4 kb] were detected by using subgenomic restriction enzyme fragments of an FIV molecular clone or FIV-specific oligonucleotides as probes. Among these transcripts, the 9...
متن کاملFeline leukemia virus and feline immunodeficiency virus.
Ophthalmic manifestations of FeLV or FIV infection can occur in all ocular tissues and may be manifestations of direct viral effects or secondary to viral-related malignant transformation. Additionally, the manifestations of common feline ophthalmic pathogens may be more severe and poorly responsive to therapy because of the immunosuppressive effects of FeLV or FIV infection. Prompt diagnosis o...
متن کاملFeline leukemia virus & feline immunodeficiency virus.
RISK OF INFECTION/EXPOSURE The risk of infection is higher in younger animals and cats that are in contact with multiple cats (strays). Generally, Feline Leukemia Virus (FeLV) is spread by casual contact between cats although as they age, resistance to infection develops. Feline Immunodeficiency Virus (FIV) is spread more commonly through bite wounds or through sexual behaviour. Exposure occurs...
متن کاملIdentification of a central DNA flap in feline immunodeficiency virus.
A duplication of the polypurine tract (PPT) at the center of the human immunodeficiency virus type 1 (HIV-1) genome (the cPPT) has been shown to prime a separate plus-strand initiation and to result in a plus-strand displacement (DNA flap) that plays a role in nuclear import of the viral preintegration complex. Feline immunodeficiency virus (FIV) is a lentivirus that infects nondividing cells, ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1991
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.65.8.4539-4542.1991